Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

@article{Griendling1994AngiotensinIS,
  title={Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.},
  author={Kathy K. Griendling and Candace A. Minieri and Jeremy D. Ollerenshaw and R. Wayne Alexander},
  journal={Circulation research},
  year={1994},
  volume={74 6},
  pages={
          1141-8
        }
}
The signaling pathways involved in the long-term metabolic effects of angiotensin II (Ang II) in vascular smooth muscle cells are incompletely understood but include the generation of molecules likely to affect oxidase activity. We examined the ability of Ang II to stimulate superoxide anion formation and investigated the identity of the oxidases responsible for its production. Treatment of vascular smooth muscle cells with Ang II for 4 to 6 hours caused a 2.7 +/- 0.4-fold increase in… Expand
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