Angiotensin II signals mechanical stretch-induced cardiac matrix metalloproteinase expression via JAK-STAT pathway.

Abstract

BACKGROUND Mechanical stress induces many pathophysiological effects in cardiomyocytes. The objective of this study was to test the hypothesis that angiotensin II is a potential mediator of stretch-induced activation of matrix metalloproteinases (MMP). METHODS Neonatal rat cardiomyocytes grown on a flexible membrane were cyclically stretched achieving up… (More)

Topics

Cite this paper

@article{Wang2004AngiotensinIS, title={Angiotensin II signals mechanical stretch-induced cardiac matrix metalloproteinase expression via JAK-STAT pathway.}, author={Tzong-Luen Wang and Yu-Hui Yang and Hang Chang and Chi-Ren Hung}, journal={Journal of molecular and cellular cardiology}, year={2004}, volume={37 3}, pages={785-94} }