Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation.

@article{Shibata2014AngiotensinIS,
  title={Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation.},
  author={Shigeru Shibata and Juan Pablo Arroyo and Mar{\'i}a Casta{\~n}eda-Bueno and Jeremy Puthumana and Junhui Zhang and Shunya Uchida and Kathryn L. Stone and TuKiet T Lam and Richard P. Lifton},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 43},
  pages={15556-61}
}
Hypertension contributes to the global burden of cardiovascular disease. Increased dietary K(+) reduces blood pressure; however, the mechanism has been obscure. Human genetic studies have suggested that the mechanism is an obligatory inverse relationship between renal salt reabsorption and K(+) secretion. Mutations in the kinases with-no-lysine 4 (WNK4) or… CONTINUE READING