Angiotensin II signaling to phospholipase D in renal microvascular smooth muscle cells in SHR.

@article{Andresen2001AngiotensinIS,
  title={Angiotensin II signaling to phospholipase D in renal microvascular smooth muscle cells in SHR.},
  author={Bradley T. Andresen and Edwin K Jackson and Guillermo G. Romero},
  journal={Hypertension},
  year={2001},
  volume={37 2 Pt 2},
  pages={635-9}
}
Angiotensin II (Ang II)-induced phospholipase D (PLD) activity is greater in aortic smooth muscle from spontaneously hypertensive rats (SHR) versus normotensive Wistar-Kyoto rats (WKY). Whether and how this signaling pathway is altered in preglomerular microvascular smooth muscle cells (PGSMCs), a cell type that may participate in genetic hypertension, is unknown. The goals of the present study were to determine in SHR and WKY PGSMCs the following: (1) whether Ang II induces PLD activity; (2… CONTINUE READING