Angiotensin II signaling in vascular smooth muscle cells under high glucose conditions.

@article{Natarajan1999AngiotensinIS,
  title={Angiotensin II signaling in vascular smooth muscle cells under high glucose conditions.},
  author={Rama Natarajan and Steven Scott and Wenlong Bai and K K Yerneni and Jerry L Nadler},
  journal={Hypertension},
  year={1999},
  volume={33 1 Pt 2},
  pages={378-84}
}
The mechanisms responsible for the accelerated cardiovascular disease in diabetes, as well as the increased hypertrophic effects of angiotensin II (Ang II) under hyperglycemic conditions, are not very clear. We examined whether the culture of vascular smooth muscle cells (VSMC) under hyperglycemic conditions to simulate the diabetic state can lead to increased activation of key growth- and stress-related kinases, such as the mitogen-activated protein kinases (MAPKs), in the basal state and in… CONTINUE READING
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p38 mitogenactivated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II

  • M Ushi-Fukai, RW Alexander, M Akers, KK. Griendling
  • J Biol Chem
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