Angiotensin II signaling and HB-EGF shedding via metalloproteinase in glomerular mesangial cells.

@article{UchiyamaTanaka2001AngiotensinIS,
  title={Angiotensin II signaling and HB-EGF shedding via metalloproteinase in glomerular mesangial cells.},
  author={Yoko Uchiyama-Tanaka and Hiroaki Matsubara and Yoshihisa Nozawa and Satoshi Murasawa and Yasukiyo Mori and Atsushi Kosaki and Katsuya Maruyama and Hiroya Masaki and Yasunoba Shibasaki and Soichiro Fujiyama and Atsuko Nose and Osamu Iba and Tomonobu Hasagawa and Eriko Tateishi and Shigeki Higashiyama and Toshiji Iwasaka},
  journal={Kidney international},
  year={2001},
  volume={60 6},
  pages={2153-63}
}
BACKGROUND Angiotensin II (Ang II) has been implicated in the development of glomerulosclerosis by stimulating fibronectin (FN) synthesis. The processing and release of heparin binding-endothelin growth factor (HB-EGF) are activated by protein kinase C (PKC) and Ca2+ signaling. We studied the roles of HB-EGF and endothelial growth factor (EGF) receptor (EGFR) in Ang II-induced FN expression using mesangial cells. METHODS Mesangial cells were prepared from mouse kidneys by the explant method… CONTINUE READING