Angiotensin II signal transduction through small GTP-binding proteins: mechanism and significance in vascular smooth muscle cells.

@article{Ohtsu2006AngiotensinIS,
  title={Angiotensin II signal transduction through small GTP-binding proteins: mechanism and significance in vascular smooth muscle cells.},
  author={Haruhiko Ohtsu and Hiroyuki Suzuki and Hidekatsu Nakashima and Sudhir Dhobale and Gerald Frank and Evangeline D. Motley and Satoru Eguchi},
  journal={Hypertension},
  year={2006},
  volume={48 4},
  pages={534-40}
}
Small GTP-binding proteins (G proteins) are monomeric G proteins with a low molecular weight of 20 to 40 kDa. A small G protein acts as a molecular switch that cycles between inactive GDP-bound and active GTP-bound forms. Thus far, 100 small G proteins have been identified in eukaryotes from yeast to humans. The small G proteins in this superfamily are structurally classified into 5 families: the Ras, Rho, Rab, Sar/Arf, and Ran families. In general, the Ras family mainly regulates gene… CONTINUE READING
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