Angiotensin II relaxes microvessels via the AT(2) receptor and Ca(2+)-activated K(+) (BK(Ca)) channels.

@article{Dimitropoulou2001AngiotensinIR,
  title={Angiotensin II relaxes microvessels via the AT(2) receptor and Ca(2+)-activated K(+) (BK(Ca)) channels.},
  author={Christiana Dimitropoulou and Richard E. White and Lena Fuchs and Haifeng Zhang and John D. Catravas and Gerald O. Carrier},
  journal={Hypertension},
  year={2001},
  volume={37 2},
  pages={301-7}
}
Angiotensin II (Ang II) is one of the most potent vasoconstrictor substances, yet paradoxically, Ang II may dilate certain vascular beds via an undefined mechanism. Ang II-induced vasoconstriction is mediated by the AT(1) receptor, whereas the relative expression and functional importance of the AT(2) receptor in regulating vascular resistance and blood pressure are unknown. We now report that Ang II induces relaxation of mesenteric microvessels and that this vasodilatory response was… CONTINUE READING