Angiotensin II receptors mediate increased distal nephron acidification caused by acid retention.

@article{Wesson2012AngiotensinIR,
  title={Angiotensin II receptors mediate increased distal nephron acidification caused by acid retention.},
  author={Donald Everett Wesson and Chan-Hee Jo and Jan Simoni},
  journal={Kidney international},
  year={2012},
  volume={82 11},
  pages={1184-94}
}
Patients with a moderately reduced glomerular filtration rate (GFR) typically have no metabolic acidosis and a urine net acid excretion comparable to those with normal GFR, supporting greater per nephron acidification with moderately reduced GFR. We modeled such patients using rats with a surgical reduction of 2/3 kidney mass, yielding animals with reduced GFR without metabolic acidosis. We then tested the hypothesis that reduction of nephron mass augments distal nephron acidification in… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Similar Papers

Loading similar papers…