Angiotensin II receptors and functional correlates.

  title={Angiotensin II receptors and functional correlates.},
  author={Pieter B. M. WW. M. Timmermans and Paul Benfield and Andrew T. Chiu and William F. Herblin and Pancras C. Wong and Ronald D Smith},
  journal={American journal of hypertension},
  volume={5 12 Pt 2},
Angiotensin II (ANG II) is the primary mediator of the renin-angiotensin system, which has an important functional role in cardiovascular homeostasis. The angiotensin receptor and its functional correlates have been redefined by the cloning of angiotensin receptors and the discovery and widespread study of specific nonpeptide ANG II-receptor antagonists losartan (AT1 selective) and PD123177 (AT2 selective). With these antagonists, it has been possible to extend the concept of ANG II-receptor… CONTINUE READING
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