Angiotensin II receptors and functional correlates.

  title={Angiotensin II receptors and functional correlates.},
  author={Pieter B.M.W.M. Timmermans and Pamela A. Benfield and Andrew T. Chiu and William F. Herblin and Pancras C Wong and R. D. Smith},
  journal={American journal of hypertension},
  volume={5 12 Pt 2},
Angiotensin II (ANG II) is the primary mediator of the renin-angiotensin system, which has an important functional role in cardiovascular homeostasis. The angiotensin receptor and its functional correlates have been redefined by the cloning of angiotensin receptors and the discovery and widespread study of specific nonpeptide ANG II-receptor antagonists losartan (AT1 selective) and PD123177 (AT2 selective). With these antagonists, it has been possible to extend the concept of ANG II-receptor… 

Angiotensin receptors: distribution, signalling and function.

Recent advances in the understanding of angiotensin II receptors are discussed, in particular, their distribution, signalling and function.

Angiotensin II Receptor Blockade: An Innovative Approach to Cardiovascular Pharmacotherapy

Clinical studies confirm the AII antagonist action ofLosartan and suggest that losartan will be effective in the treatment of essential HTN, and the utility of AII antagonism may extend beyond that of HTN and CHF, as suggested by the potential usefulness of angiotensin‐converting enzyme inhibition.

Medicinal Chemistry of Angiotensin II Antagonists

The renin—angiotensin system (RAS) has been demonstrated to be a key element in blood pressure regulation and sodium balance and several compounds from the Takeda series were reported to inhibit the ANG II-induced contractile response in rabbit aorta and the pressor response in the Ang II-infused rat, but no information on selectivity was provided.

Liver disease and the renin–angiotensin system: Recent discoveries and clinical implications

The present review focuses on the novel components and pathways of the RAS with particular reference to their potential contribution towards the pathophysiology of liver disease.

AT1-receptor blockers: differences that matter

  • A. Gradman
  • Medicine, Biology
    Journal of Human Hypertension
  • 2002
Pharmacological differences between AT1-receptor blockers are reflected in clinically important differences in maximal antihypertensive effect, response rate, and duration of action.

Angiotensin-Converting Enzyme Inhibitors an Angiotensin II-Receptor Antagonists

The inhibition of the RAAS at the level of the transmitter-receptor interaction seems to be a logical development because nonpeptide (ie, orally active) angiotensin II (AT) receptor antagonists are available and this concept can be proven.

Overview of angiotensin II-receptor antagonists.

Angiotensin II receptor blockade and ventricular remodelling

By blocking at the receptor level, Ang II receptor blockers (ARBs) provide an alternative and more direct approach to inhibiting the effects of Ang II; however, data relating to their effects upon ventricular remodelling are less convincing.