• Corpus ID: 1015128

Angiotensin II receptors and angiotensin II receptor antagonists.

  title={Angiotensin II receptors and angiotensin II receptor antagonists.},
  author={Pieter B.M.W.M. Timmermans and Pancras C Wong and Andrew T. Chiu and William F. Herblin and Pamela A. Benfield and David John Carini and R J Lee and Ruth R. Wexler and Jo Anne Saye and R. D. Smith},
  journal={Pharmacological reviews},
  volume={45 2},

Mas receptor antagonist (A799) alters the renal hemodynamics responses to angiotensin II administration after renal moderate ischemia/reperfusion in rats: gender related differences

The important role of Mas receptor in renal vascular response to Ang II in female rats after moderate I/R is suggested, and these responses were not altered statistically in dual blockade of MasR and AT2R.

Kinin B1 receptor upregulation by angiotensin II and endothelin-1 in rat vascular smooth muscle cells: receptors and mechanisms.

B(1)R induction is linked to oxidative stress and activation of phosphatidylinositol 3-kinase and NF-κB and can activate MAPK signaling in VSMC.

Irbesartan inhibits human T‐lymphocyte activation through downregulation of activator protein‐1

The studies show that irbesartan may modulate inflammation‐based atherosclerotic diseases through a cell‐mediated mechanism involving suppression of human T‐lymphocytes activation via downregulation of AP‐1 activity.

Effects of ANG II and III and angiotensin receptor blockers on nasal salt gland secretion and arterial blood pressure in conscious Pekin ducks (Anas platyrhynchos)

An important role of the nasal salt glands in potassium regulation is substantiated and a pharmacological dimorphism of saralasin is highlighted, namely agonist and antagonist to angiotensin II-mediated inhibition of nasal salt gland function and pressor response, respectively.

Activation of Ca(2+)-activated K+ (maxi-K+) channel by angiotensin II in myocytes of the guinea pig ileum.

The preservation of the pharmacomechanical coupling of ANG II in these cells provides a good model for the study of transmembrane signaling responses to ANG II and analogs in this tissue.

Phosphorylation of p 130 Cas by Angiotensin II Is Dependent on cSrc , Intracellular Ca 2 1 , and Protein Kinase C

These results are the first to demonstrate that the tyrosine phosphorylation of p130 Cas by Ang II is transduced by the Src, intracellular Ca, protein kinase C signaling pathway.

Differential gene expression and regulation of angiotensin II receptor subtypes in rat cardiac fibroblasts and cardiomyocytes in culture.

Data indicate that AngII receptor subtype expression in the rat heart is regulated in a cell- and subtype-specific manner.

Local ocular renin–angiotensin–aldosterone system: any connection with intraocular pressure? A comprehensive review

Evidence is accumulating that the local ocular RAAS is involved in aqueous humour dynamics, regulation of intraocular pressure, neuroprotection and ocular pathology making components of RAAS attractive candidates when developing new effective ways to treat glaucoma.

Involvement of Spinal Angiotensin II System in Streptozotocin-Induced Diabetic Neuropathic Pain in Mice

Results indicate that the expression of spinal ACE increased in STZ-induced diabetic mice, which in turn led to an increase in Ang II levels and tactile allodynia, which was shown to be mediated by AT1 receptors.