• Corpus ID: 1015128

Angiotensin II receptors and angiotensin II receptor antagonists.

  title={Angiotensin II receptors and angiotensin II receptor antagonists.},
  author={Pieter B.M.W.M. Timmermans and Pancras C Wong and Andrew T. Chiu and William F. Herblin and Pamela A. Benfield and David John Carini and R J Lee and Ruth R. Wexler and Jo Anne Saye and Ronald D. Smith},
  journal={Pharmacological reviews},
  volume={45 2},
Mas receptor antagonist (A799) alters the renal hemodynamics responses to angiotensin II administration after renal moderate ischemia/reperfusion in rats: gender related differences
The important role of Mas receptor in renal vascular response to Ang II in female rats after moderate I/R is suggested, and these responses were not altered statistically in dual blockade of MasR and AT2R.
Kinin B1 receptor upregulation by angiotensin II and endothelin-1 in rat vascular smooth muscle cells: receptors and mechanisms.
B(1)R induction is linked to oxidative stress and activation of phosphatidylinositol 3-kinase and NF-κB and can activate MAPK signaling in VSMC.
Irbesartan inhibits human T‐lymphocyte activation through downregulation of activator protein‐1
The studies show that irbesartan may modulate inflammation‐based atherosclerotic diseases through a cell‐mediated mechanism involving suppression of human T‐lymphocytes activation via downregulation of AP‐1 activity.
Activation of Ca(2+)-activated K+ (maxi-K+) channel by angiotensin II in myocytes of the guinea pig ileum.
The preservation of the pharmacomechanical coupling of ANG II in these cells provides a good model for the study of transmembrane signaling responses to ANG II and analogs in this tissue.
Effects of ANG II and III and angiotensin receptor blockers on nasal salt gland secretion and arterial blood pressure in conscious Pekin ducks (Anas platyrhynchos)
An important role of the nasal salt glands in potassium regulation is substantiated and a pharmacological dimorphism of saralasin is highlighted, namely agonist and antagonist to angiotensin II-mediated inhibition of nasal salt gland function and pressor response, respectively.
Phosphorylation of p 130 Cas by Angiotensin II Is Dependent on cSrc , Intracellular Ca 2 1 , and Protein Kinase C
p130 is a signaling molecule that was initially found to be tyrosine-phosphorylated in v-Crk and v-Src transformed cells. We characterized the regulation of p130 Cas tyrosine phosphorylation in
Involvement of Spinal Angiotensin II System in Streptozotocin-Induced Diabetic Neuropathic Pain in Mice
Results indicate that the expression of spinal ACE increased in STZ-induced diabetic mice, which in turn led to an increase in Ang II levels and tactile allodynia, which was shown to be mediated by AT1 receptors.
Attenuation of L-Type Ca2+ Channel Expression and Vasomotor Response in the Aorta with Age in Both Wistar-Kyoto and Spontaneously Hypertensive Rats
It is provided the first evidence that aging caused a reduction of VDCC expression in rat aorta, irrespective of the rat strain, along with diminishment of the therapeutic potential of V DCC blockers.
Vasopressor meets vasodepressor: The AT1-B2 receptor heterodimer.
Specific targeting of the AT1R-B2R heterodimer became feasible and could open the way to a new class of drugs, which specifically interfere with pathological angiotensin II-AT1 receptor system activation.