Angiotensin II receptor type 1 blockers suppress the cell proliferation effects of angiotensin II in breast cancer cells by inhibiting AT1R signaling.

@article{Du2012AngiotensinIR,
  title={Angiotensin II receptor type 1 blockers suppress the cell proliferation effects of angiotensin II in breast cancer cells by inhibiting AT1R signaling.},
  author={Ning Du and Jiang Feng and Li-juan Hu and Xin Sun and Hai-bing Sun and Yang Zhao and Yi-Ping Yang and Hong Ren},
  journal={Oncology reports},
  year={2012},
  volume={27 6},
  pages={
          1893-903
        }
}
Chronic stress and a high-fat diet are well-documented risk factors associated with the renin-angiotensin system in the development of breast cancer. The angiotensin II type 1 receptor (AT1R) is a novel component of the renin-angiotensin system. Several recent studies have focused on the function of AT1R in cell proliferation during cancer development. Thus, we hypothesized that angiotensin II (Ang Ⅱ) can promote proliferation of breast cancer via activated AT1R; the activation of AT1R may play… 
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