Angiotensin II receptor subtypes.

@article{Timmermans1992AngiotensinIR,
  title={Angiotensin II receptor subtypes.},
  author={Pieter B.M.W.M. Timmermans and Andrew T. Chiu and William F. Herblin and Pancras C Wong and R. D. Smith},
  journal={American journal of hypertension},
  year={1992},
  volume={5 6 Pt 1},
  pages={
          406-10
        }
}
The octapeptide, angiotensin II (Ang II), the biologically active component of the renin-angiotensin system, elicits its multiple actions through the stimulation of specific surface receptors on various target organs. Although the existence of Ang II receptor subtypes has been suspected for some time, definitive evidence for Ang II receptor heterogeneity has been obtained only with the recently introduced nonpeptide Ang II receptor antagonists, exemplified by the prototypic compounds DuP 753… 

Angiotensin II Receptor Blockade: An Innovative Approach to Cardiovascular Pharmacotherapy

Clinical studies confirm the AII antagonist action ofLosartan and suggest that losartan will be effective in the treatment of essential HTN, and the utility of AII antagonism may extend beyond that of HTN and CHF, as suggested by the potential usefulness of angiotensin‐converting enzyme inhibition.

Characterization of nuclear angiotensin-II-binding sites in rat liver and comparison with plasma membrane receptors.

The nuclear Ang-II-binding site in purified nuclei preparation from rat liver is characterized and it is shown to consist of soluble protein releasable from nuclei by freezing and thawing, hence distinct in physicochemical properties from the membrane-bound receptor.

Medicinal Chemistry of Angiotensin II Antagonists

The renin—angiotensin system (RAS) has been demonstrated to be a key element in blood pressure regulation and sodium balance and several compounds from the Takeda series were reported to inhibit the ANG II-induced contractile response in rabbit aorta and the pressor response in the Ang II-infused rat, but no information on selectivity was provided.

Angiotensin II receptor pharmacology and AT1-receptor blockers

In neuronal cell lines, the AT2 receptor reportedly exerts antiproliferative effects and promotes neurite outgrowth, an effect accompanied by significant changes in the gene expression pattern of growth- and differentiation-related genes.

Angiotensin II receptor inhibition. A new therapeutic principle.

It seems likely that the angiotensin receptor antagonists will be added to the list of drugs that have been deemed suitable for first-line therapy in the treatment of hypertension and congestive heart failure.

The past, present and future of angiotensin II type 2 receptor stimulation

An overview of the first results obtained by direct AT2 receptor stimulation with Compound 21, comprising effects on alkaline secretion, neurite outgrowth, blood pressure and post-infarct cardiac function.
...