Angiotensin II receptor subtypes in the rat brain.

  title={Angiotensin II receptor subtypes in the rat brain.},
  author={Brian P. Rowe and Kevin L. Grove and D L Saylor and Robert C Speth},
  journal={European journal of pharmacology},
  volume={186 2-3},
The non-peptide angiotensin II (AII) receptor subtype selective antagonist, DuP 753, was used to characterize AII receptor binding sites in the rat brain. DuP 753 competed for specific 125I-[Sar1,Ile8]AII (125I-SIAII) binding in many brain nuclei (IC50 = 20-30 nM), but was a weak competitor at remaining sites (IC50 greater than 10(-4) M). DuP 753 sensitive binding sites (designated AII alpha subtype) correspond with areas where binding is inhibited by sulfhydryl reducing agents, whereas DuP 753… CONTINUE READING

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