Angiotensin II receptor blockade reduces salt sensitivity of blood pressure through restoration of renal nitric oxide synthesis in patients with diabetic nephropathy.

@article{Imanishi2013AngiotensinIR,
  title={Angiotensin II receptor blockade reduces salt sensitivity of blood pressure through restoration of renal nitric oxide synthesis in patients with diabetic nephropathy.},
  author={Masahito Imanishi and Noriyuki Okada and Yoshio Konishi and Takashi Morikawa and Isseki Maeda and Chizuko Kitabayashi and Masahiro Masada and Nobuo Shirahashi and Christopher Stuart Wilcox and Akira Nishiyama},
  journal={Journal of the renin-angiotensin-aldosterone system : JRAAS},
  year={2013},
  volume={14 1},
  pages={67-73}
}
INTRODUCTION We have previously demonstrated the increased salt sensitivity of blood pressure (BP) in diabetic patients with early nephropathy. Here, we examined the effects of an angiotensin II receptor blocker (ARB) on salt sensitivity and renal oxidative stress or nitric oxide (NO) in those patients. PATIENTS AND METHODS Type 2 diabetic patients with (n = 6) and without (n = 6) microalbuminuria were studied on a high-salt diet for one week and on a salt-restricted diet for one week. The… CONTINUE READING
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