Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression

@inproceedings{Yabumoto2015AngiotensinIR,
  title={Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression},
  author={Chizuru Yabumoto and Hiroshi Akazawa and Rie Yamamoto and Masamichi Yano and Yoko Kudo-Sakamoto and Tomokazu Sumida and Takehiro Kamo and Hiroki Yagi and Yu Shimizu and Akiko Saga-Kamo and Atsuhiko Thomas Naito and Toru Oka and Jong-Kook Lee and Jun-Ichi Suzuki and Yasushi Sakata and Etsuko Uejima and Issei Komuro},
  booktitle={Scientific reports},
  year={2015}
}
Disruption of angiotensin II type 1 (AT1) receptor prolonged life span in mice. Since aging-related decline in skeletal muscle function was retarded in Atgr1a(-/-) mice, we examined the role of AT1 receptor in muscle regeneration after injury. Administration of AT1 receptor blocker irbesartan increased the size of regenerating myofibers, decreased fibrosis, and enhanced functional muscle recovery after cryoinjury. We recently reported that complement C1q, secreted by macrophages, activated Wnt… CONTINUE READING