Angiotensin II receptor antagonists

@article{Burnier2000AngiotensinIR,
  title={Angiotensin II receptor antagonists},
  author={Michel Antoine Burnier and Hr Dipl Chem Brunner},
  journal={The Lancet},
  year={2000},
  volume={355},
  pages={637-645}
}
Blockade of the renin-angiotensin system began as a way of studying the pathogenesis of cardiovascular disease with specific pharmacological probes. Oral activity, achieved by shortening the original peptide structures, transformed the probes into therapeutic agents, the angiotensin-converting enzyme (ACE) inhibitors. However, ACE is a non-specific target for blocking the renin-angiotensin enzymatic cascade. The availability of orally active drugs turned ACE inhibition into a therapeutic… CONTINUE READING
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