Angiotensin II receptor antagonist delays renal damage and stroke in salt-loaded Dahl salt-sensitive rats.

@article{Lutterotti1992AngiotensinIR,
  title={Angiotensin II receptor antagonist delays renal damage and stroke in salt-loaded Dahl salt-sensitive rats.},
  author={Nicola von Lutterotti and Marcelo Camargo and Wallace G. Campbell and F B Mueller and Pieter B. M. WW. M. Timmermans and Jean E. Sealey and John H. Laragh},
  journal={Journal of hypertension},
  year={1992},
  volume={10 9},
  pages={949-57}
}
OBJECTIVE To study the effects of blockade of the renin-angiotensin system upon the development of hypertension, end-organ damage and mortality in Dahl salt-sensitive (DSS) rats using an angiotensin II receptor antagonist, losartan. DESIGN AND METHODS DSS rats (n = 186) were fed 8% NaCl from 6 to 16 weeks of age. One group received losartan whilst the control group was untreated. Changes in blood pressure and plasma renin activity (PRA), as well as renal and cerebrovascular damage and… CONTINUE READING

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