Angiotensin II plays a critical role in alcohol-induced cardiac nitrative damage, cell death, remodeling, and cardiomyopathy in a protein kinase C/nicotinamide adenine dinucleotide phosphate oxidase-dependent manner.

@article{Tan2012AngiotensinIP,
  title={Angiotensin II plays a critical role in alcohol-induced cardiac nitrative damage, cell death, remodeling, and cardiomyopathy in a protein kinase C/nicotinamide adenine dinucleotide phosphate oxidase-dependent manner.},
  author={Yi Tan and Xiaokun Li and Sumanth D. Prabhu and Kenneth R. Brittian and Qiang Chen and Xia Yin and C J Mcclain and Zhanxiang 3 Zhou and Lu Cai},
  journal={Journal of the American College of Cardiology},
  year={2012},
  volume={59 16},
  pages={1477-86}
}
OBJECTIVES The purpose of this study was to examine the cellular and molecular mechanisms underlying alcoholic cardiomyopathy. BACKGROUND The mechanism for alcoholic cardiomyopathy remains largely unknown. METHODS The chronic cardiac effects of alcohol were examined in mice feeding with alcohol or isocaloric control diet for 2 months. Signaling pathways of alcohol-induced cardiac cell death were examined in H9c2 cells. RESULTS Compared with controls, hearts from alcohol-fed mice exhibited… CONTINUE READING
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