Angiotensin II modulates renal sympathetic neurotransmission through nitric oxide in AT2 receptor knockout mice.

@article{Stegbauer2005AngiotensinIM,
  title={Angiotensin II modulates renal sympathetic neurotransmission through nitric oxide in AT2 receptor knockout mice.},
  author={Johannes Stegbauer and Oliver Vonend and Sina Habbel and Ivo Quack and Lorenz Sellin and Volkmar Gross and Lars Christian Rump},
  journal={Journal of hypertension},
  year={2005},
  volume={23 9},
  pages={1691-8}
}
OBJECTIVE Angiotensin (Ang) II enhances renal sympathetic neurotransmission and stimulates nitric oxide (NO) release. The present study investigates whether Ang II-mediated modulation of sympathetic neurotransmission is dependent on NO production in the kidney. AT2 -/y receptor-deficient mice are used to identify the Ang II receptor subtype involved. METHODS Mice kidneys were isolated and perfused with Krebs-Henseleit solution. Drugs were added to the perfusion solution in a cumulative manner… CONTINUE READING