Angiotensin II modulates catecholamine release into interstitial fluid of canine myocardium in vivo.

@article{Farrell2001AngiotensinIM,
  title={Angiotensin II modulates catecholamine release into interstitial fluid of canine myocardium in vivo.},
  author={Diane M. Farrell and Chih Chang Wei and Jose A. Tallaj and Jeffrey L Ardell and John A. Armour and Gilbert R. Hageman and Wayne E. Bradley and Louis J. Dell'Italia},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={281 2},
  pages={H813-22}
}
This study tested the hypothesis that exogenous infusion of angiotensin II (ANG II) leads to the release of catecholamines [norepinephrine (NE) and epinephrine (EPI)] into the cardiac interstitial fluid (ISF) space of dogs with adrenals intact (AI) (n = 7) and with adrenals clamped (AC) (n = 5). LV ISF samples were collected at 3-min intervals during administration of ANG II (100 microM ANG II at 1 ml/min for 10 min) to right atrial neurons via their local arterial blood supply and during… CONTINUE READING