Angiotensin II modulates BBB permeability via activation of the AT(1) receptor in brain endothelial cells.

Abstract

Hypertensive encephalopathy occurs when acute changes in blood pressure cause breakdown of the blood-brain barrier (BBB). Angiotensin II (Ang II) plays a role in this pathophysiology. We determined whether Ang II directly regulates endothelial cell function at the BBB. In BBB microvessel endothelial cells (MECs), the Ang II (100 nmol/L; 0 to 6 h) effects on… (More)
DOI: 10.1038/jcbfm.2008.158

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