Angiotensin II-mediated oxidative DNA damage accelerates cellular senescence in cultured human vascular smooth muscle cells via telomere-dependent and independent pathways.

@article{Herbert2008AngiotensinIO,
  title={Angiotensin II-mediated oxidative DNA damage accelerates cellular senescence in cultured human vascular smooth muscle cells via telomere-dependent and independent pathways.},
  author={Karl E. Herbert and Yogita Mistry and Richard P Hastings and Toryn M Poolman and Laura Niklason and Bryan P Williams},
  journal={Circulation research},
  year={2008},
  volume={102 2},
  pages={201-8}
}
Angiotensin II (Ang II) induces reactive oxygen species (ROS) production by human vascular smooth muscle cells (hVSMCs). ROS have been implicated in the development of both acute stress-induced premature senescence (SIPS) and chronic replicative senescence. Global oxidative DNA damage triggers SIPS and telomere DNA damage accelerates replicative senescence, both mediated via p53. This study tests the hypothesis that DNA is an important target for Ang II-induced ROS leading to senescence via… CONTINUE READING
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