Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

@article{Rajagopalan1996AngiotensinIH,
  title={Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.},
  author={Sanjay Rajagopalan and Stefan Kurz and Thomas F. M{\"u}nzel and Margaret Tarpey and Bruce A. Freeman and Kathy K. Griendling and David G Harrison},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 8},
  pages={1916-23}
}
We tested the hypothesis that angiotensin II-induced hypertension is associated with an increase in vascular .O2- production, and characterized the oxidase involved in this process. Infusion of angiotensin II (0.7 mg/kg per d) increased systolic blood pressure and doubled vascular .O2- production (assessed by lucigenin chemiluminescence), predominantly from the vascular media. NE infusion (2.75 mg/kg per d) produced a similar degree of hypertension, but did not increase vascular .O2- production… CONTINUE READING
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