Angiotensin II inhibits satellite cell proliferation and prevents skeletal muscle regeneration.

  title={Angiotensin II inhibits satellite cell proliferation and prevents skeletal muscle regeneration.},
  author={Tadashi Yoshida and Sarah E Galvez and Sumit Tiwari and Bashir M. Rezk and Laura C Semprun-Prieto and Yusuke Higashi and Sergiy Sukhanov and Zipora Yablonka-Reuveni and Patrice Delafontaine},
  journal={The Journal of biological chemistry},
  volume={288 33},
Cachexia is a serious complication of many chronic diseases, such as congestive heart failure (CHF) and chronic kidney disease (CKD). Although patients with advanced CHF or CKD often have increased angiotensin II (Ang II) levels and cachexia and Ang II causes skeletal muscle wasting in rodents, the potential effects of Ang II on muscle regeneration are unknown. Muscle regeneration is highly dependent on the ability of a pool of muscle stem cells (satellite cells) to proliferate and to repair… CONTINUE READING

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