Angiotensin-II inhibits Na+/K+ pump in rat adrenal glomerulosa cells: possible contribution to stimulation of aldosterone production.

@article{Hajnczky1992AngiotensinIIIN,
  title={Angiotensin-II inhibits Na+/K+ pump in rat adrenal glomerulosa cells: possible contribution to stimulation of aldosterone production.},
  author={Gyorgy Hajn{\'o}czky and Gy{\"o}rgy Csord{\'a}s and L{\'a}szl{\'o} Hunyady and Mikl{\'o}s P{\'e}ter Kalapos and Tamas Balla and P{\'e}ter Enyedi and Andr{\'a}s Sp{\"a}t},
  journal={Endocrinology},
  year={1992},
  volume={130 3},
  pages={1637-44}
}
The control of Na+/K+ pump activity was studied in rat adrenal glomerulosa cells. Ninety percent of K+/86Rb accumulation was blocked by ouabain, and the dose-response curve of inhibition by ouabain was monophasic (IC50, approximately 80 microM), suggesting the role of a single type of Na+/K+ pump (alpha-isoenzyme) in 86Rb accumulation by rat glomerulosa cells. The basal activity of the Na+/K+ pump was much higher in glomerulosa cells than in adrenal fasciculata cells or hepatocytes, as judged… CONTINUE READING

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