Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1.

@article{Tan2008AngiotensinIP,
  title={Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1.},
  author={Nicole Y Tan and Valerie C. Midgley and Mary Meltem Kavurma and Fernando S. Santiago and Xiao Luo and Ryan Peden and Roger G Fahmy and Michael C. Berndt and Mark P. Molloy and Levon M. Khachigian},
  journal={Circulation research},
  year={2008},
  volume={102 4},
  pages={e38-51}
}
Sp1, the first identified and cloned transcription factor, regulates gene expression via multiple mechanisms including direct protein-DNA interactions, protein-protein interactions, chromatin remodeling, and maintenance of methylation-free CpG islands. Sp1 is itself regulated at different levels, for example, by glycosylation, acetylation, and phosphorylation by kinases such as the atypical protein kinase C-zeta. Although Sp1 controls the basal and inducible regulation of many genes, the… CONTINUE READING