Angiotensin II induces the generation of procoagulant microparticles by human mononuclear cells via an angiotensin type 2 receptor-mediated pathway.

@article{Cordazzo2013AngiotensinII,
  title={Angiotensin II induces the generation of procoagulant microparticles by human mononuclear cells via an angiotensin type 2 receptor-mediated pathway.},
  author={Cinzia Cordazzo and Tommaso Neri and Silvia Petrini and Stefania Lombardi and Cristina Bal{\`i}a and Silvana Cianchetti and Yuri Carmazzi and Pierluigi L Paggiaro and Roberto Pedrinelli and Alessandro Celi},
  journal={Thrombosis research},
  year={2013},
  volume={131 4},
  pages={e168-74}
}
INTRODUCTION Microparticles are small vesicles shed by cells upon activation and during apoptosis which participate in physiologically relevant phenomena, including blood coagulation. Intracellular calcium mobilization is one of the mechanisms of microparticle generation during cell activation. Because the renin-angiotensin system has been proposed as a link between hypertension and increased thrombotic risk, we investigated whether angiotensin II upregulates the generation of procoagulant… CONTINUE READING

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