Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy.

@article{Zhou2007AngiotensinII,
  title={Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy.},
  author={Cissy Chenyi Zhou and Shakil Ahmad and Tiejuan Mi and Lingwei Xia and Shahrzad Abbasi and Peter W. Hewett and Chunxiao Sun and Asif Ahmed and Rodney E. Kellems and Yang Xia},
  journal={Circulation research},
  year={2007},
  volume={100 1},
  pages={88-95}
}
Maternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor and placental growth factor. Angiotensin II (Ang II) is a potent vasoconstrictor that increases concomitant with sFlt-1 during pregnancy. Therefore, we speculated that Ang II may promote the expression of sFlt-1 in pregnancy. Here we report that infusion of Ang II significantly increases circulating levels of… CONTINUE READING

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Preeclampsia: Updates in Pathogenesis, Definitions, and Guidelines.

Clinical journal of the American Society of Nephrology : CJASN • 2016
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References

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New insights into the biology of preeclampsia

H Stepan, R Faber, +3 authors T. Walther
Biol Reprod • 2006

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