Angiotensin II induces histomorphologic features of unstable plaque in a murine model of accelerated atherosclerosis.

@article{Cunha2006AngiotensinII,
  title={Angiotensin II induces histomorphologic features of unstable plaque in a murine model of accelerated atherosclerosis.},
  author={Valdeci da Cunha and Baby Martin-McNulty and Jon Vincelette and David Choy and We-Wei Li and Miriam Schroeder and Mithra Mahmoudi and Meredith Halks-Miller and Dennis W. Wilson and Ronald Vergona and Mark E. Sullivan and Yi-Xin Jim Wang},
  journal={Journal of vascular surgery},
  year={2006},
  volume={44 2},
  pages={364-71}
}
BACKGROUND We explored the role of angiotensin II in determining the histomorphometric features of plaque stability in apolipoprotein E-deficient mice submitted to ligation of the carotid artery. METHODS Six-month-old apolipoprotein E-deficient mice underwent ligation of the common left carotid artery and were immediately assigned to receive either angiotensin II (1.4 mg . kg(-1) . d(-1) subcutaneously) or vehicle (phosphate-buffered saline; control) via a subcutaneous osmotic minipump for 4… CONTINUE READING
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