Angiotensin II induces histomorphologic features of unstable plaque in a murine model of accelerated atherosclerosis.


BACKGROUND We explored the role of angiotensin II in determining the histomorphometric features of plaque stability in apolipoprotein E-deficient mice submitted to ligation of the carotid artery. METHODS Six-month-old apolipoprotein E-deficient mice underwent ligation of the common left carotid artery and were immediately assigned to receive either… (More)