Angiotensin II induces formation of the early growth response gene-1 protein in rat vascular smooth muscle cells.

@article{Sachinidis1992AngiotensinII,
  title={Angiotensin II induces formation of the early growth response gene-1 protein in rat vascular smooth muscle cells.},
  author={Agapios Sachinidis and Paul T. Weisser and Yu-shien Ko and Kathleen Schulte and K Meyer zu Brickwedde and Ludwig Neyses and Hans Vetter},
  journal={FEBS letters},
  year={1992},
  volume={313 2},
  pages={109-12}
}
The effect of angiotensin II (Ang II) on the early growth response gene-1 (Egr-1) mRNA, on the Egr-1 protein and on the phosphoinositide PI turnover signalling system was investigated in the presence and absence of EXP3174, a potent non-peptide Ang II receptor antagonist. Ang II induced an accumulation of 3.4 kb Egr-1 mRNA and the 80 kDa Egr-1 protein, with a maximum at 30 min and 60 min, respectively. EXP3174 blocked the Ang II-induced increase of inositol phosphates, Egr-1 mRNA and the Egr-1… CONTINUE READING