Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway.

@article{Hu2007AngiotensinII,
  title={Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway.},
  author={Chang-ping Hu and Abhijit Dandapat and Jawahar Lal Mehta},
  journal={Hypertension},
  year={2007},
  volume={50 5},
  pages={952-7}
}
Angiotensin II (Ang II) induces angiogenesis by stimulating reactive oxygen species-dependent vascular endothelial growth factor (VEGF) expression. Ang II via type 1 receptor upregulates the expression of LOX-1, a lectin-like receptor for oxidized low-density lipoprotein. LOX-1 activation, in turn, upregulates Ang II type 1 receptor expression. We postulated that interruption of the feedback loop between Ang II and LOX-1 might attenuate Ang II-induced VEGF expression and capillary formation. In… CONTINUE READING

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