Angiotensin II induces apoptosis in rat glomerular epithelial cells.

  title={Angiotensin II induces apoptosis in rat glomerular epithelial cells.},
  author={Guohua Ding and K. Raghunandan Reddy and Aditi A. Kapasi and Nicholas Franki and Nora E Gibbons and Balakuntalam S Kasinath and Pravin C. Singhal},
  journal={American journal of physiology. Renal physiology},
  volume={283 1},
ANG II has been shown to modulate kidney cell growth and contribute to the pathobiology of glomerulosclerosis. Glomerular visceral epithelial cell (GEC) injury or loss is considered to play a pivotal role in the initiation and progression of glomerulosclerosis. In the present study, we investigated the effect of ANG II on GEC apoptosis. Rat GECs were incubated with increasing doses of ANG II for variable time periods. Apoptosis was evaluated by cell nucleus staining and DNA fragmentation assay… CONTINUE READING
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Glomerulosclerosis at both early and late stage is associated F179 ANG II AND GEC APOPTOSIS AJP-Renal Physiol

  • CM Pesce, L Striker, E Peter, S Elliot, GE. Striker
  • Lab Invest
  • 2002
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