Angiotensin II induces NF-kappa B activation in HUVEC via the p38MAPK pathway.

@article{Guo2006AngiotensinII,
  title={Angiotensin II induces NF-kappa B activation in HUVEC via the p38MAPK pathway.},
  author={Rui-wei Guo and Lixia Yang and Maoquan Li and Bei Liu and Xian-mei Wang},
  journal={Peptides},
  year={2006},
  volume={27 12},
  pages={3269-75}
}
Angiotensin II (Ang II) is the main active peptide of the renin-angiotensin system (RAS), producing a number of inflammatory mediators that lead to endothelial dysfunction and the progression of atherosclerosis. Ang II-induced NF-kappaB nuclear translocation plays a pivotal role in this response. This study examines the NF-kappaB activation mechanism elicited by Ang II in human umbilical vein endothelial cells (HUVEC). Electrophoretic mobility shift assays and Western blotting revealed that Ang… CONTINUE READING