Angiotensin II-induced stimulation of p21-activated kinase and c-Jun NH2-terminal kinase is mediated by Rac1 and Nck.

@article{Schmitz2001AngiotensinIS,
  title={Angiotensin II-induced stimulation of p21-activated kinase and c-Jun NH2-terminal kinase is mediated by Rac1 and Nck.},
  author={Udo Schmitz and Kerstin Th{\"o}mmes and Imke Beier and Wolfgang Wagner and Agapios Sachinidis and Rainer D{\"u}sing and Henning Vetter},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 25},
  pages={22003-10}
}
p21-activated kinase (PAK) has been shown to be an upstream mediator of JNK in angiotensin II (AngII) signaling. Little is known regarding other signaling molecules involved in activation of PAK and JNK by AngII. Rho family GTPases Rac and Cdc42 have been shown to enhance PAK activity by binding to p21-binding domain of PAK (PAK-PBD). In vascular smooth muscle cells (VSMC) AngII stimulated Rac1 binding to GST-PAK-PBD fusion protein. Pretreatment of VSMC by genistein inhibited AngII-induced Rac1… CONTINUE READING

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