Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling.

@article{Ogihara2002AngiotensinII,
  title={Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling.},
  author={Takehide Ogihara and Tomoichiro Asano and Katsuyuki Ando and Yuko Chiba and Hideyuki Sakoda and Motonobu Anai and Nobuhiro Shojima and Hiraku Ono and Yukiko Onishi and Midori Fujishiro and Hideki Katagiri and Yasushi Fukushima and Masatoshi Kikuchi and Noriko Noguchi and Hiroyuki Aburatani and Issei Komuro and Toshiro Fujita},
  journal={Hypertension},
  year={2002},
  volume={40 6},
  pages={872-9}
}
Angiotensin II (AII) is involved in the pathogenesis of both hypertension and insulin resistance, though few studies have examined the relationship between the two. We therefore investigated the effects of chronic AII infusion on blood pressure and insulin sensitivity in rats fed a normal (0.3% NaCl) or high-salt (8% NaCl) diet. AII infusion for 12 days significantly elevated blood pressure and significant insulin resistance, assessed by a hyperinsulinemic-euglycemic clamp study and glucose… CONTINUE READING