Angiotensin II-induced hypertension regulates AT1 receptor subtypes and extracellular matrix turnover in mouse retinal pigment epithelium.

@article{Praddaude2009AngiotensinIH,
  title={Angiotensin II-induced hypertension regulates AT1 receptor subtypes and extracellular matrix turnover in mouse retinal pigment epithelium.},
  author={Françoise Praddaude and Scott W. Cousins and Christiane P{\^e}cher and Maria E. Marin-Casta{\~n}o},
  journal={Experimental eye research},
  year={2009},
  volume={89 1},
  pages={
          109-18
        }
}
Accumulation of specific deposits and extracellular molecules under the retinal pigment epithelium (RPE) has been previously observed in eyes with age-related macular degeneration (AMD) and may play a role in the pathogenesis of AMD. Even though age is the major determinant for developing AMD, clinical studies have revealed hypertension (HTN) as another systemic risk factor. Angiotensin II (Ang II) is considered the most important hormone associated with HTN. To evaluate the relationship of Ang… CONTINUE READING

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