Angiotensin II increases glomerular permeability by β-arrestin mediated nephrin endocytosis

  title={Angiotensin II increases glomerular permeability by β-arrestin mediated nephrin endocytosis},
  author={E. K{\"o}nigshausen and Ulf M. Zierhut and Martin Ruetze and S. Potthoff and J. Stegbauer and M. Woznowski and I. Quack and L. C. Rump and L. Sellin},
  journal={Scientific Reports},
  • E. Königshausen, Ulf M. Zierhut, +6 authors L. Sellin
  • Published 2016
  • Chemistry, Medicine
  • Scientific Reports
  • Glomerular permeability and subsequent albuminuria are early clinical markers for glomerular injury in hypertensive nephropathy. Albuminuria predicts mortality and cardiovascular morbidity. AT1 receptor blockers protect from albuminuria, cardiovascular morbidity and mortality. A blood pressure independent, molecular mechanism for angiotensin II (Ang II) dependent albuminuria has long been postulated. Albuminuria results from a defective glomerular filter. Nephrin is a major structural component… CONTINUE READING
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