Angiotensin II enhances beta-adrenergic receptor-mediated vasorelaxation in aortas from young but not old rats.

@article{Schutzer2000AngiotensinIE,
  title={Angiotensin II enhances beta-adrenergic receptor-mediated vasorelaxation in aortas from young but not old rats.},
  author={William E. Schutzer and Hong Xue and John F. Reed and Jean Baptiste Roullet and Sharon Anderson and Scott L. Mader},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={279 6},
  pages={H2807-14}
}
beta-Adrenergic receptor (beta-AR)-mediated (cAMP-dependent) vasorelaxation declines with advancing age. It has been shown that angiotensin II (ANG II), a potent vasoconstrictor, enhances cAMP-mediated vasorelaxation. Therefore, we questioned whether ANG II could reverse age-related, impaired beta-AR-mediated vasorelaxation and cAMP production. Pretreatment of aortic rings from 6-wk-old or 6-mo-old male Fischer 344 rats with ANG II significantly enhanced vasorelaxation induced by isoproterenol… CONTINUE READING