Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18.

@article{Valente2012AngiotensinIE,
  title={Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18.},
  author={Anthony J Valente and Tadashi Yoshida and Subramanyam N. Murthy and Siva Sankara Vara Prasad Sakamuri and Masato Katsuyama and Robert A. Clark and Patrice Delafontaine and Bysani Chandrasekar},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2012},
  volume={303 3},
  pages={H282-96}
}
The redox-sensitive transcription factors NF-κB and activator protein-1 (AP-1) are critical mediators of ANG II signaling. The promitogenic and promigratory factor interleukin (IL)-18 is an NF-κB- and AP-1-responsive gene. Therefore, we investigated whether ANG II-mediated smooth muscle cell (SMC) migration and proliferation involve IL-18. ANG II induced rat carotid artery SMC migration and proliferation and IL-18 and metalloproteinase (MMP)-9 expression via ANG II type 1 (AT(1)) receptor. ANG… CONTINUE READING
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