Angiotensin II-dependent hypertension requires cyclooxygenase 1-derived prostaglandin E2 and EP1 receptor signaling in the subfornical organ of the brain.

@article{Cao2012AngiotensinIH,
  title={Angiotensin II-dependent hypertension requires cyclooxygenase 1-derived prostaglandin E2 and EP1 receptor signaling in the subfornical organ of the brain.},
  author={Xian Cao and Jeffrey R. Peterson and Gang Wang and Josef Anrather and Colin N Young and Mallikarjuna R. Guruju and Melissa A Burmeister and Costantino Iadecola and Robin L. Davisson},
  journal={Hypertension},
  year={2012},
  volume={59 4},
  pages={
          869-76
        }
}
Cyclooxygenase (COX)-derived prostanoids have long been implicated in blood pressure (BP) regulation. Recently prostaglandin E(2) (PGE(2)) and its receptor EP(1) (EP(1)R) have emerged as key players in angiotensin II (Ang II)-dependent hypertension (HTN) and related end-organ damage. However, the enzymatic source of PGE(2,) that is, COX-1 or COX-2, and its site(s) of action are not known. The subfornical organ (SFO) is a key forebrain region that mediates systemic Ang II-dependent HTN via… CONTINUE READING

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  • American journal of physiology. Regulatory, integrative and comparative physiology
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COX-1-derived PGE2 and PGE2 type 1 receptors are vital for angiotensin II-induced formation of reactive oxygen species and Ca(2+) influx in the subfornical organ.

Gang Wang, Pallabi Sarkar, +9 authors Robin L. Davisson
  • American journal of physiology. Heart and circulatory physiology
  • 2013
VIEW 9 EXCERPTS
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