Angiotensin II contributes to diabetic renal dysfunction in rodents and humans via Notch1/Snail pathway.

@article{Gagliardini2013AngiotensinIC,
  title={Angiotensin II contributes to diabetic renal dysfunction in rodents and humans via Notch1/Snail pathway.},
  author={Elena Gagliardini and Norberto Perico and Paola Del Rizzo and Simona Buelli and Lorena Longaretti and Luca Perico and Susanna Tomasoni and Carlamaria Zoja and Daniela Macconi and Marina Morigi and Giuseppe Remuzzi and Ariela Benigni},
  journal={The American journal of pathology},
  year={2013},
  volume={183 1},
  pages={
          119-30
        }
}
In nondiabetic rat models of renal disease, angiotensin II (Ang II) perpetuates podocyte injury and promotes progression to end-stage kidney disease. Herein, we wanted to explore the role of Ang II in diabetic nephropathy by a translational approach spanning from in vitro to in vivo rat and human studies, and to dissect the intracellular pathways involved. In isolated perfused rat kidneys and in cultured human podocytes, Ang II down-regulated nephrin expression via Notch1 activation and nuclear… CONTINUE READING
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