Angiotensin II blocks ATP-sensitive K+ channels in porcine coronary artery smooth muscle cells.

@article{Miyoshi1991AngiotensinIB,
  title={Angiotensin II blocks ATP-sensitive K+ channels in porcine coronary artery smooth muscle cells.},
  author={Yasuhide Miyoshi and Yutaka Nakaya},
  journal={Biochemical and biophysical research communications},
  year={1991},
  volume={181 2},
  pages={700-6}
}
ATP-sensitive K+ channels with small conductance (30 pS in symmetrical K(+)-rich solutions) in porcine coronary artery smooth muscle cells were highly active at physiological concentrations of Ca2+ (greater than 10(-4) M) even in the presence of physiological ATP levels, suggesting that these channels contribute to the generation of the resting membrane potential in vascular smooth muscle cells and their modulation is important in controlling vasomotor tone. Angiotensin II, applied from outside… CONTINUE READING
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