Angiotensin II and the endothelium: diverse signals and effects.

  title={Angiotensin II and the endothelium: diverse signals and effects.},
  author={Tetsu Watanabe and Thomas A. Barker and Bradford C. Berk},
  volume={45 2},
The initial view of the renin-angiotensin system focused on the role of angiotensin II as a hormone involved in blood pressure control, based on its role in renal salt and water regulation, as well as central nervous system (thirst) and vascular smooth muscle tone. Subsequent data showed a role for angiotensin II in long-term effects on cardiovascular structure, including cardiac hypertrophy and vascular remodeling. Importantly, recent human studies with angiotensin-converting enzyme inhibitors… CONTINUE READING