Angiotensin II and potassium regulate human CYP11B2 transcription through common cis-elements.

@article{Clyne1997AngiotensinIA,
  title={Angiotensin II and potassium regulate human CYP11B2 transcription through common cis-elements.},
  author={Colin Clyne and Yin Zhang and Laurence Slutsker and J Michael Mathis and Perrin C White and William E. Rainey},
  journal={Molecular endocrinology},
  year={1997},
  volume={11 5},
  pages={638-49}
}
Aldosterone synthase is a mitochondrial enzyme that catalyzes the conversion of 11-deoxycorticosterone to the potent mineralocorticoid aldosterone. The gene encoding aldosterone synthase, CYP11B2, is expressed in the zona glomerulosa of the adrenal cortex. Although the major physiological regulators of aldosterone production are angiotensin II (ANG II) and potassium (K+), the mechanisms by which these compounds regulate CYP11B2 transcription are unknown. Therefore we analyzed the human CYP11B2… CONTINUE READING

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