Angiotensin II and its receptor subtypes in the human retina.

  title={Angiotensin II and its receptor subtypes in the human retina.},
  author={Preenie deS Senanayake and Judy A. Drazba and Karen G. Shadrach and Amy Milsted and Elisabeth Rungger-Brandle and Kazutoshi Nishiyama and Shin-ichiro Miura and Sadashiva Karnik and Jonathan E. Sears and Joe G. Hollyfield},
  journal={Investigative ophthalmology & visual science},
  volume={48 7},
PURPOSE To quantify and evaluate the distribution of angiotensin II (Ang II) and its receptors in the human retina. METHODS Donor eyes were obtained within 12 hours postmortem and classified as hypertensive or normotensive and diabetic or nondiabetic, based on the donors' medical histories. Ang II in retina and vitreous was quantified by RIA. Ang II receptors were characterized and quantified by competitive membrane-binding assays. Ang II, its heptapeptide metabolite Ang-(1-7), and AT1 and… CONTINUE READING