Angiotensin II and extracellular matrix homeostasis.

  title={Angiotensin II and extracellular matrix homeostasis.},
  author={Karl T. Weber and Shivalingappa K. Swamynathan and Ramareddy V. Guntaka and Yun Sun},
  journal={The international journal of biochemistry & cell biology},
  volume={31 3-4},
As a circulating hormone, endocrine properties of angiotensin (Ang) II are integral to circulatory homeostasis. Produced de novo its autocrine/paracrine properties contribute to biologic responses involving various connective tissues (e.g. extracellular matrix, adipose tissue, bone and its marrow). In this brief review, we develop the concept of extracellular matrix homeostasis, a self regulation of cellular composition and structure, wherein fibroblast-derived AngII regulates elaboration of… CONTINUE READING

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