Angiotensin II and CRF receptors in the central nucleus of the amygdala mediate hemodynamic response variability to cocaine in conscious rats.

@article{Watanabe2010AngiotensinIA,
  title={Angiotensin II and CRF receptors in the central nucleus of the amygdala mediate hemodynamic response variability to cocaine in conscious rats.},
  author={Mari A. Watanabe and Sarah Kucenas and Tamara A. Bowman and Melissa K Ruhlman and Mark M Knuepfer},
  journal={Brain research},
  year={2010},
  volume={1309},
  pages={53-65}
}
Stress or cocaine evokes either a large increase in systemic vascular resistance (SVR) or a smaller increase in SVR accompanied by an increase in cardiac output (designated vascular and mixed responders, respectively) in Sprague-Dawley rats. We hypothesized that the central nucleus of the amygdala (CeA) mediates this variability. Conscious, freely-moving rats, instrumented for measurement of arterial pressure and cardiac output and for drug delivery into the CeA, were given cocaine (5 mg/kg, iv… CONTINUE READING