Angiotensin II activates extracellular signal regulated kinases via protein kinase C and epidermal growth factor receptor in breast cancer cells.

@article{Greco2003AngiotensinIA,
  title={Angiotensin II activates extracellular signal regulated kinases via protein kinase C and epidermal growth factor receptor in breast cancer cells.},
  author={Simona Greco and Antonella Muscella and Maria Giovanna Elia and Paola Salvatore and Carlo Storelli and Annamaria Mazzotta and Claudia Manca and Santo Marsigliante},
  journal={Journal of cellular physiology},
  year={2003},
  volume={196 2},
  pages={370-7}
}
Angiotensin II (Ang II) induces, through AT1, intracellular Ca(2+) increase in both normal and cancerous breast cells in primary culture (Greco et al., 2002 Cell Calcium 2:1-10). We here show that Ang II stimulated, in a dose-dependent manner, the 24 h-proliferation of breast cancer cells in primary culture, induced translocation of protein kinase C (PKC)-alpha, -beta1/2, and delta (but not -epsilon, -eta, -theta, -zeta, and -iota), and phosphorylated extracellular-regulated kinases 1 and 2… CONTINUE READING